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Using a pooled genome-wide scan of 500,288single-nucleotide polymorphisms, a major risk locus wasidentified in chromosome 11p12-p11 (Melquiest et al.,2007). (2003) Neuro-imaging and early diagnosis of Alzheimer disease: a look to thefuture. (2003) Psychosocial riskfactors of HIV morbidity and mortality: Findings from the mul-ticenter AIDS cohort study (MACS). The ability of the older adult tofunction in everyday activities, albeit with environmental andpharmacologic interventions, is a more meaningful measureof normalcy than are physical ?ndings alone.

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